Three-dimensional endomicroscopy of the human colon using optical coherence tomography

Desmond C. Adler, Chao Zhou, Tsung Han Tsai, Joe Schmitt, Qin Huang, Hiroshi Mashimo, James G. Fujimoto

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


Three-dimensional (3D) endomicroscopy imaging of the human gastrointestinal tract is demonstrated in vivo using a swept source optical coherence tomography (OCT) system. 3D datasets of normal and pathologic regions of the colon, rectum, and anal verge were obtained from seven volunteers undergoing diagnostic or therapeutic colonoscopy. 3D-OCT enables high resolution endomicroscopy examination through visualization of tissue architectural morphology using virtual cross-sectional images with arbitrary orientations as well as en face projection images. Axial image resolutions of 6 Qn in tissue are obtained over a -180 mm2 field with an imaging range of 1.6 mm. A Fourier domain mode locked (FDML) laser providing a tuning range of 180 nm at a sweep rate of 62 kHz is used as the system light source. This clinical pilot study demonstrates the potential of 3D-OCT for distinguishing normal from pathologic colorectal tissue, assessing endoscopic therapies and healing progression.

Original languageEnglish
Pages (from-to)784-786
Number of pages3
JournalOptics Express
Issue number2
StatePublished - Jan 19 2009


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