Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans

Tricia A. Missall, Jennifer K. Lodge

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Thioredoxin reductase (TRR1) is an important component of the thioredoxin oxidative stress resistance pathway. Here we show that it is induced during oxidative and nitrosative stress and is preferentially localized to the mitochondria in Cryptococcus neoformans. The C. neoformans TRR1 gene encodes the low-molecular-weight isoform of the thioredoxin reductase enzyme, which shares little homology with that of its mammalian host. By replacing the endogenous TRR1 promoter with an inducible copper transporter promoter, we showed that Trr1 appears to be essential for viability of this pathogenic fungus, making it a potential antifungal target.

Original languageEnglish
Pages (from-to)487-489
Number of pages3
JournalEukaryotic Cell
Volume4
Issue number2
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

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