TY - JOUR
T1 - Thinner Retinal Nerve Fiber Layer in Very Preterm Versus Term Infants and Relationship to Brain Anatomy and Neurodevelopment
AU - Rothman, Adam L.
AU - Sevilla, Monica B.
AU - Mangalesh, Shwetha
AU - Gustafson, Kathryn E.
AU - Edwards, Laura
AU - Cotten, C. Michael
AU - Shimony, Joshua S.
AU - Pizoli, Carolyn E.
AU - El-Dairi, Mays A.
AU - Freedman, Sharon F.
AU - Toth, Cynthia A.
N1 - Funding Information:
THE ANDREWFAMily Charitable Foundation (Framingham, Massachusetts); Research to Prevent Blindness (New York, New York); Grant Number 1UL1RR024128-01 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH, Bethesda, Maryland); and NIH Roadmap for Medical Research (Bethesda, Maryland). The Eunice Kennedy Shriver National Institute of ChildHealth&Human Development (Rockville, Maryland) of the National Institutes of Health supported both Dr Shimony, under the P30HD062171 to the Intellectual and Developmental Disabilities Research Center atWashington University, and Drs Cotten and Gustafson, under the 5U10 HD040492-10 to Duke University. Dr Shimony also received funding from The McDonnell Centers for Systems Neuroscience and Cellular&Molecular Neurobiology (St Louis, Missouri). All contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH. The sponsors or funding organizations had no role in the design or conduct of this research. Financial Disclosures: Cynthia A. Toth receives royalties through her university from Alcon and research support from Bioptigen (Research Triangle Park, North Carolina) and Genentech (South San Francisco, California). She also has unlicensed patents pending in OCT imaging and analysis. Mays A. El-Dairi has served as a consultant for Prana Pharmaceuticals (Parkville, Australia). The following authors have no financial disclosures: Adam L. Rothman, Monica B. Sevilla, Shwetha Mangalesh, Kathryn E. Gustafson, Laura Edwards, C. Michael Cotten, Joshua S. Shimony, Carolyn E. Pizoli, and Sharon F. Freedman. All authors attest that they meet the current ICMJE criteria for authorship. The authors would like to thank Sina Farsiu, PhD (Duke University Eye Center), for use of segmentation software; Sandra S. Stinnett, DrPH (Duke University Eye Center), for statistics consultation; Amy Tong, MD (Duke University Eye Center), and Du Tran-Viet, BS (Duke University Eye Center), for data acquisition; and Vincent Tai, MS (Duke University Eye Center), for assistance with image processing. All authors attest that they meet the current ICMJE requirements to qualify as authors.
Funding Information:
Funding/Support: Dr Toth was supported by The Hartwell Foundation (Memphis, Tennessee); The Andrew Family Charitable Foundation (Framingham, Massachusetts); Research to Prevent Blindness (New York, New York); Grant Number 1UL1RR024128-01 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH, Bethesda, Maryland); and NIH Roadmap for Medical Research (Bethesda, Maryland). The Eunice Kennedy Shriver National Institute of Child Health & Human Development (Rockville, Maryland) of the National Institutes of Health supported both Dr Shimony, under the P30HD062171 to the Intellectual and Developmental Disabilities Research Center at Washington University, and Drs Cotten and Gustafson, under the 5U10 HD040492-10 to Duke University. Dr Shimony also received funding from The McDonnell Centers for Systems Neuroscience and Cellular & Molecular Neurobiology (St Louis, Missouri). All contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH. The sponsors or funding organizations had no role in the design or conduct of this research. Financial Disclosures: Cynthia A. Toth receives royalties through her university from Alcon and research support from Bioptigen (Research Triangle Park, North Carolina) and Genentech (South San Francisco, California). She also has unlicensed patents pending in OCT imaging and analysis. Mays A. El-Dairi has served as a consultant for Prana Pharmaceuticals (Parkville, Australia). The following authors have no financial disclosures: Adam L. Rothman, Monica B. Sevilla, Shwetha Mangalesh, Kathryn E. Gustafson, Laura Edwards, C. Michael Cotten, Joshua S. Shimony, Carolyn E. Pizoli, and Sharon F. Freedman. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - Purpose To assess retinal nerve fiber layer (RNFL) thickness at term-equivalent age in very preterm (<32 weeks gestational age) vs term-born infant cohorts, and compare very preterm infant RNFL thickness with brain anatomy and neurodevelopment. Design Cohort study. Methods RNFL was semi-automatically segmented (1 eye per infant) in 57 very preterm and 50 term infants with adequate images from bedside portable, handheld spectral-domain optical coherence tomography imaging at 37-42 weeks postmenstrual age. Mean RNFL thickness was calculated for the papillomacular bundle (-15 degrees to +15 degrees) and temporal quadrant (-45 degrees to +45 degrees) relative to the fovea-optic nerve axis. Brain magnetic resonance imaging (MRI) scans clinically obtained in 26 very preterm infants were scored for global structural abnormalities by an expert masked to data except for age. Cognitive, language, and motor skills were assessed in 33 of the very preterm infants at 18-24 months corrected age. Results RNFL was thinner for very preterm vs term infants at the papillomacular bundle ([mean ± standard deviation] 61 ± 17 vs 72 ± 13 μm, P <.001) and temporal quadrant (72 ± 21 vs 82 ± 16 μm, P =.005). In very preterm infants, thinner papillomacular bundle RNFL correlated with higher global brain MRI lesion burden index (R2 = 0.35, P =.001) and lower cognitive (R2 = 0.18, P =.01) and motor (R2 = 0.17, P =.02) scores. Relationships were similar for temporal quadrant. Conclusions Thinner RNFL in very preterm infants relative to term-born infants may relate to brain structure and neurodevelopment.
AB - Purpose To assess retinal nerve fiber layer (RNFL) thickness at term-equivalent age in very preterm (<32 weeks gestational age) vs term-born infant cohorts, and compare very preterm infant RNFL thickness with brain anatomy and neurodevelopment. Design Cohort study. Methods RNFL was semi-automatically segmented (1 eye per infant) in 57 very preterm and 50 term infants with adequate images from bedside portable, handheld spectral-domain optical coherence tomography imaging at 37-42 weeks postmenstrual age. Mean RNFL thickness was calculated for the papillomacular bundle (-15 degrees to +15 degrees) and temporal quadrant (-45 degrees to +45 degrees) relative to the fovea-optic nerve axis. Brain magnetic resonance imaging (MRI) scans clinically obtained in 26 very preterm infants were scored for global structural abnormalities by an expert masked to data except for age. Cognitive, language, and motor skills were assessed in 33 of the very preterm infants at 18-24 months corrected age. Results RNFL was thinner for very preterm vs term infants at the papillomacular bundle ([mean ± standard deviation] 61 ± 17 vs 72 ± 13 μm, P <.001) and temporal quadrant (72 ± 21 vs 82 ± 16 μm, P =.005). In very preterm infants, thinner papillomacular bundle RNFL correlated with higher global brain MRI lesion burden index (R2 = 0.35, P =.001) and lower cognitive (R2 = 0.18, P =.01) and motor (R2 = 0.17, P =.02) scores. Relationships were similar for temporal quadrant. Conclusions Thinner RNFL in very preterm infants relative to term-born infants may relate to brain structure and neurodevelopment.
UR - http://www.scopus.com/inward/record.url?scp=84945974441&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2015.09.015
DO - 10.1016/j.ajo.2015.09.015
M3 - Article
C2 - 26386157
AN - SCOPUS:84945974441
SN - 0002-9394
VL - 160
SP - 1296-1308.e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 6
ER -