TY - JOUR
T1 - Thinking within the D box
T2 - Initial identification of Cdh1-APC substrates in the nervous system
AU - Kim, Albert H.
AU - Bonni, Azad
N1 - Funding Information:
The authors’ research is funded by an NIH grant (NS 051255, to A.B.), the Christopher Reeve Foundation (A.B.), and the Ruth L. Kirschstein NRSA Research Training Grant, NCI (A.H.K.). We thank members of the Bonni laboratory for editorial assistance and insightful discussions during the preparation of the manuscript.
PY - 2007/3
Y1 - 2007/3
N2 - The anaphase-promoting complex (APC) has a well-established role in cell cycle control, but recent exciting evidence has uncovered unexpected neurobiological functions for this complex E3 ubiquitin ligase. With its co-activator Cdh1, APC's effects upon the nervous system range from regulation of axon growth and patterning to development of synapses to neuronal survival. The Cdh1-APC substrates that control these biological processes in neurons are just beginning to be identified. These findings may offer a glimpse of the wide spectrum of neural activities that are orchestrated by Cdh1-APC.
AB - The anaphase-promoting complex (APC) has a well-established role in cell cycle control, but recent exciting evidence has uncovered unexpected neurobiological functions for this complex E3 ubiquitin ligase. With its co-activator Cdh1, APC's effects upon the nervous system range from regulation of axon growth and patterning to development of synapses to neuronal survival. The Cdh1-APC substrates that control these biological processes in neurons are just beginning to be identified. These findings may offer a glimpse of the wide spectrum of neural activities that are orchestrated by Cdh1-APC.
UR - http://www.scopus.com/inward/record.url?scp=33847633885&partnerID=8YFLogxK
U2 - 10.1016/j.mcn.2006.11.019
DO - 10.1016/j.mcn.2006.11.019
M3 - Review article
C2 - 17223572
AN - SCOPUS:33847633885
SN - 1044-7431
VL - 34
SP - 281
EP - 287
JO - Molecular and Cellular Neuroscience
JF - Molecular and Cellular Neuroscience
IS - 3
ER -