Thermodynamic fluctuations in a reacting system measurement by fluorescence correlation spectroscopy

Douglas Magde, Elliot Elson, W. W. Webb

Research output: Contribution to journalArticlepeer-review

1438 Scopus citations

Abstract

The temporal correlations of thermodynamic concentration fluctuations have been measured in a chemically reactive system at equilibrium by observing fluctuations of the fluorescence of a reaction product. The experiment yields the chemical rate constants and diffusion coefficients and shows the coupling among them. Data are reported for binding of ethidium bromide to DNA.

Original languageEnglish
Pages (from-to)705-708
Number of pages4
JournalPhysical Review Letters
Volume29
Issue number11
DOIs
StatePublished - 1972

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