Thermal ablation versus surgical resection for localized hepatocellular carcinoma: A population study using the SEER database

Abigail Mills; David Thayer; Christopher Noda; Amber Salter; Yu Tao; Minzhi Xing; Robert Martin; Raja Ramaswamy; Olaguoke Akinwande

doi:10.2217/fon-2017-0447

Thermal ablation versus surgical resection for localized hepatocellular carcinoma: A population study using the SEER database

Abigail Mills, David Thayer, Christopher Noda, Amber Salter, Yu Tao, Minzhi Xing, Robert Martin, Raja Ramaswamy, Olaguoke Akinwande

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aim: To compare overall survival (OS) and liver cancer-specific survival (LCSS) in patients with localized hepatocellular carcinoma treated with surgical resection (SR) or thermal ablation (TA) using the Surveillance, Epidemiology and End Results database. Materials & methods: Kaplan-Meier, competing risk and Cox regression analyses were performed after identifying patients. Propensity score matching was then applied. Results: There was significantly better OS in the SR group and significantly lower probability of LCSS in the TA group. After matching, there was significantly longer OS in the SR group and a lower probability of LCSS in the TA group. Conclusion: SR offered a significant survival benefit over TA for localized hepatocellular carcinoma.

Original language	English
Pages (from-to)	631-645
Number of pages	15
Journal	Future Oncology
Volume	14
Issue number	7
DOIs	https://doi.org/10.2217/fon-2017-0447
State	Published - Mar 2018

Keywords

cryoablation
hepatocellular carcinoma
radiofrequency ablation
surgical resection
survival
thermal ablation

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title = "Thermal ablation versus surgical resection for localized hepatocellular carcinoma: A population study using the SEER database",

abstract = "Aim: To compare overall survival (OS) and liver cancer-specific survival (LCSS) in patients with localized hepatocellular carcinoma treated with surgical resection (SR) or thermal ablation (TA) using the Surveillance, Epidemiology and End Results database. Materials & methods: Kaplan-Meier, competing risk and Cox regression analyses were performed after identifying patients. Propensity score matching was then applied. Results: There was significantly better OS in the SR group and significantly lower probability of LCSS in the TA group. After matching, there was significantly longer OS in the SR group and a lower probability of LCSS in the TA group. Conclusion: SR offered a significant survival benefit over TA for localized hepatocellular carcinoma.",

keywords = "cryoablation, hepatocellular carcinoma, radiofrequency ablation, surgical resection, survival, thermal ablation",

author = "Abigail Mills and David Thayer and Christopher Noda and Amber Salter and Yu Tao and Minzhi Xing and Robert Martin and Raja Ramaswamy and Olaguoke Akinwande",

note = "Funding Information: This study was exempted from institutional review board approval and was completed in accordance with the National Cancer Institute SEER user agreement. Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

month = mar,

doi = "10.2217/fon-2017-0447",

language = "English",

volume = "14",

pages = "631--645",

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TY - JOUR

T1 - Thermal ablation versus surgical resection for localized hepatocellular carcinoma

T2 - A population study using the SEER database

AU - Mills, Abigail

AU - Thayer, David

AU - Noda, Christopher

AU - Salter, Amber

AU - Tao, Yu

AU - Xing, Minzhi

AU - Martin, Robert

AU - Ramaswamy, Raja

AU - Akinwande, Olaguoke

N1 - Funding Information: This study was exempted from institutional review board approval and was completed in accordance with the National Cancer Institute SEER user agreement. Publisher Copyright: © 2018 2018 Future Medicine Ltd.

PY - 2018/3

Y1 - 2018/3

N2 - Aim: To compare overall survival (OS) and liver cancer-specific survival (LCSS) in patients with localized hepatocellular carcinoma treated with surgical resection (SR) or thermal ablation (TA) using the Surveillance, Epidemiology and End Results database. Materials & methods: Kaplan-Meier, competing risk and Cox regression analyses were performed after identifying patients. Propensity score matching was then applied. Results: There was significantly better OS in the SR group and significantly lower probability of LCSS in the TA group. After matching, there was significantly longer OS in the SR group and a lower probability of LCSS in the TA group. Conclusion: SR offered a significant survival benefit over TA for localized hepatocellular carcinoma.

AB - Aim: To compare overall survival (OS) and liver cancer-specific survival (LCSS) in patients with localized hepatocellular carcinoma treated with surgical resection (SR) or thermal ablation (TA) using the Surveillance, Epidemiology and End Results database. Materials & methods: Kaplan-Meier, competing risk and Cox regression analyses were performed after identifying patients. Propensity score matching was then applied. Results: There was significantly better OS in the SR group and significantly lower probability of LCSS in the TA group. After matching, there was significantly longer OS in the SR group and a lower probability of LCSS in the TA group. Conclusion: SR offered a significant survival benefit over TA for localized hepatocellular carcinoma.

KW - cryoablation

KW - hepatocellular carcinoma

KW - radiofrequency ablation

KW - surgical resection

KW - survival

KW - thermal ablation

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JO - Future Oncology

JF - Future Oncology

IS - 7

ER -

Thermal ablation versus surgical resection for localized hepatocellular carcinoma: A population study using the SEER database

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Keywords

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