Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke

Joshua A. Stone; Joshua Z. Willey; Salah Keyrouz; James Butera; Ryan A. McTaggart; Shawna Cutting; Brian Silver; Bradford Thompson; Karen L. Furie; Shadi Yaghi

doi:10.1007/s11940-017-0438-5

Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke

Joshua A. Stone, Joshua Z. Willey, Salah Keyrouz, James Butera, Ryan A. McTaggart, Shawna Cutting, Brian Silver, Bradford Thompson, Karen L. Furie, Shadi Yaghi

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Hemorrhagic transformation occurs in about 10–15% of patients with acute ischemic stroke. The treatment of hemorrhagic conversion is complex and includes blood pressure management, reversing coagulopathy, and managing its complications including increased intracranial pressure. Future research should be directed on identifying indications to treat and use of appropriate homeostatic regimens to effectively reverse the different anticoagulants and thrombolytic agents in an attempt to improve outcomes of patients with hemorrhagic transformation.

Original language	English
Article number	1
Journal	Current Treatment Options in Neurology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/s11940-017-0438-5
State	Published - Jan 1 2017

Keywords

Anticoagulation
Hemorrhagic transformation
Ischemic stroke
Thrombolytic therapy
Treatment

Access to Document

10.1007/s11940-017-0438-5

Cite this

@article{774bc46e6f274410b0b83303b440dec9,

title = "Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke",

abstract = "Hemorrhagic transformation occurs in about 10–15% of patients with acute ischemic stroke. The treatment of hemorrhagic conversion is complex and includes blood pressure management, reversing coagulopathy, and managing its complications including increased intracranial pressure. Future research should be directed on identifying indications to treat and use of appropriate homeostatic regimens to effectively reverse the different anticoagulants and thrombolytic agents in an attempt to improve outcomes of patients with hemorrhagic transformation.",

keywords = "Anticoagulation, Hemorrhagic transformation, Ischemic stroke, Thrombolytic therapy, Treatment",

author = "Stone, {Joshua A.} and Willey, {Joshua Z.} and Salah Keyrouz and James Butera and McTaggart, {Ryan A.} and Shawna Cutting and Brian Silver and Bradford Thompson and Furie, {Karen L.} and Shadi Yaghi",

note = "Funding Information: Joshua Z. Willey received funding from the NIH (NINDS K23NS 073104). Funding Information: Shadi Yaghi received funding from the New York Stroke Trials Network of Columbia and Cornell (NYCCSTN, NINDS U10NS086728). Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media New York.",

year = "2017",

month = jan,

day = "1",

doi = "10.1007/s11940-017-0438-5",

language = "English",

volume = "19",

journal = "Current Treatment Options in Neurology",

issn = "1092-8480",

number = "1",

}

TY - JOUR

T1 - Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke

AU - Stone, Joshua A.

AU - Willey, Joshua Z.

AU - Keyrouz, Salah

AU - Butera, James

AU - McTaggart, Ryan A.

AU - Cutting, Shawna

AU - Silver, Brian

AU - Thompson, Bradford

AU - Furie, Karen L.

AU - Yaghi, Shadi

N1 - Funding Information: Joshua Z. Willey received funding from the NIH (NINDS K23NS 073104). Funding Information: Shadi Yaghi received funding from the New York Stroke Trials Network of Columbia and Cornell (NYCCSTN, NINDS U10NS086728). Publisher Copyright: © 2017, Springer Science+Business Media New York.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Hemorrhagic transformation occurs in about 10–15% of patients with acute ischemic stroke. The treatment of hemorrhagic conversion is complex and includes blood pressure management, reversing coagulopathy, and managing its complications including increased intracranial pressure. Future research should be directed on identifying indications to treat and use of appropriate homeostatic regimens to effectively reverse the different anticoagulants and thrombolytic agents in an attempt to improve outcomes of patients with hemorrhagic transformation.

AB - Hemorrhagic transformation occurs in about 10–15% of patients with acute ischemic stroke. The treatment of hemorrhagic conversion is complex and includes blood pressure management, reversing coagulopathy, and managing its complications including increased intracranial pressure. Future research should be directed on identifying indications to treat and use of appropriate homeostatic regimens to effectively reverse the different anticoagulants and thrombolytic agents in an attempt to improve outcomes of patients with hemorrhagic transformation.

KW - Anticoagulation

KW - Hemorrhagic transformation

KW - Ischemic stroke

KW - Thrombolytic therapy

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85010962137&partnerID=8YFLogxK

U2 - 10.1007/s11940-017-0438-5

DO - 10.1007/s11940-017-0438-5

M3 - Review article

C2 - 28130682

AN - SCOPUS:85010962137

SN - 1092-8480

VL - 19

JO - Current Treatment Options in Neurology

JF - Current Treatment Options in Neurology

IS - 1

M1 - 1

ER -

Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this