Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

Thomas G. Scorer, Kristin M. Reddoch-Cardenas, Kimberly A. Thomas, Andrew P. Cap, Philip C. Spinella

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Bleeding related to thrombocytopenia is common in hematology-oncology patients. Platelets stored at room temperature (RTPs) are the current standard of care. Platelets stored in the cold (CSPs) have enhanced hemostatic function relative to RTPs. CSPs were reported to reduce bleeding in hematology-oncology patients. Recent studies have confirmed the enhanced hemostatic properties of CSPs. CSPs may be the better therapeutic option for this population. CSPs may also offer a preferable immune profile, reduced thrombotic risk, and reduced transfusion-transmitted infection risk. The logistical advantages of CSPs would improve outcomes for many patients who currently cannot access platelet transfusions.

Original languageEnglish
Pages (from-to)873-885
Number of pages13
JournalHematology/Oncology Clinics of North America
Volume33
Issue number5
DOIs
StatePublished - Oct 2019

Keywords

  • Bleeding
  • Cold-stored platelets
  • Oncology
  • Platelet storage
  • Platelet transfusion
  • Thrombocytopenia

Fingerprint

Dive into the research topics of 'Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient'. Together they form a unique fingerprint.

Cite this