Therapeutic efficacy as predicted by quantitative assessment of murine RIF-1 tumour pH and phosphorous metabolite response during hyperthermia: An in vivo 31P NMR study

T. Bezabeh, J. L. Evelhoch, P. Thompson, D. J. Sloop, J. J.H. Ackerman

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Described herein are the initial findings from an 'in-magnet' 31P NMR compatible hyperthermia system capable of concurrently heating and monitoring the metabolic response of murine tumours; the murine radiation induced fibrosarcoma (RIF-1) was employed for these studies. At thermal doses sufficient to raise tumour temperature to 41.5 and 43°C for a period of 30 min, a marked and rapid decrease in nucleoside triphosphate concentration and in pH was observed during the heating period, while inorganic phosphate concentration increased significantly but more gradually. These 31P NMR determined metabolic indices remained depressed/elevated throughout a 1.5 h post-hyperthermia monitoring period. Importantly, these metabolic indices correlated significantly with specific growth delay. This suggests a possible role for NMR spectroscopy in early assessment, and perhaps control, of therapeutic response to hyperthermia.

Original languageEnglish
Pages (from-to)335-357
Number of pages23
JournalInternational Journal of Hyperthermia
Volume20
Issue number4
DOIs
StatePublished - Jun 1 2004

Keywords

  • Bayesian analysis
  • Specific growth delay
  • Surviving fraction
  • Therapeutic response
  • Thermal dose

Fingerprint Dive into the research topics of 'Therapeutic efficacy as predicted by quantitative assessment of murine RIF-1 tumour pH and phosphorous metabolite response during hyperthermia: An in vivo <sup>31</sup>P NMR study'. Together they form a unique fingerprint.

  • Cite this