5 patients with end-stage renal disease, undergoing hemodialysis were studied sequentially; the skeletal response to chronic 25OHD3 therapy was quantitated histologically and compared to both bone collagen-mineral maturation profiles and bone mineral content. Biochemically, the bone mineral-collagen maturational profiles reverted toward normal in all 5 patients after 25OHD3 therapy, and the bone calcium content as well as Ca/P ratio was increased, coincident with the clinical pattern of a progressive increase in intestinal calcium absorption and a decrease in circulating iPTH and alkaline phosphatase. In that bone maturational profile changes were highly significant in all patients following 25OHD3 therapy, while histological changes were not striking in all patients, particularly in those with minimal pretreatment morphological evidence of osteodystrophy, measurements of mineral-collagen density-gradient profiles may prove complimentary to histometric analyses in detecting early skeletal changes in the uremic patient.
|Number of pages||10|
|Journal||Mineral and Electrolyte Metabolism|
|State||Published - Jan 1 1978|