TY - JOUR
T1 - Therapeutic drugs for targeting chloroquine resistance in malaria
AU - Sharma, Vijay
PY - 2005/4
Y1 - 2005/4
N2 - While the post-genomic era could lead into new targets for antimalarial drug development, herein few successful targets including medicinals involved in those processes are presented. Further, contribution of bioinorganic chemistry has also started to make its impact in the field of pharmaceuticals. Therefore, metal chelators, selected organometallics, and metalloantimalarials that would offer potential therapeutic drugs are also discussed. Finally, a brief summary on chloroquine-resistance mechanism(s) has been included.
AB - While the post-genomic era could lead into new targets for antimalarial drug development, herein few successful targets including medicinals involved in those processes are presented. Further, contribution of bioinorganic chemistry has also started to make its impact in the field of pharmaceuticals. Therefore, metal chelators, selected organometallics, and metalloantimalarials that would offer potential therapeutic drugs are also discussed. Finally, a brief summary on chloroquine-resistance mechanism(s) has been included.
KW - Chloroquine
KW - Drug-resistance
KW - Malaria
KW - Metalloantimalarials
KW - Therapeutic drugs
UR - http://www.scopus.com/inward/record.url?scp=16444370249&partnerID=8YFLogxK
U2 - 10.2174/1389557053544029
DO - 10.2174/1389557053544029
M3 - Review article
C2 - 15853624
AN - SCOPUS:16444370249
SN - 1389-5575
VL - 5
SP - 337
EP - 351
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 4
ER -