Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

Jeff C. Kremer; Brian A. Van Tine

doi:10.1080/23723556.2017.1295131

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

Jeff C. Kremer, Brian A. Van Tine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously increasing glutamine metabolism via the tricarboxylic acid cycle. Simultaneous arginine deprivation and inhibition of the subsequent metabolic adaptations induce synthetic lethality.

Original language	English
Article number	e1295131
Journal	Molecular and Cellular Oncology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2017.1295131
State	Published - May 4 2017

Keywords

ADI-PEG20
ASS1
GLS
PHGDH
Warburg
arginine deiminase
argininosuccinate synthetase 1
glucose
glutaminase
glutamine
metabolism

Access to Document

10.1080/23723556.2017.1295131

Cite this

@article{982fd59bcce0490bb4618b79a4344c68,

title = "Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect",

abstract = "Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously increasing glutamine metabolism via the tricarboxylic acid cycle. Simultaneous arginine deprivation and inhibition of the subsequent metabolic adaptations induce synthetic lethality.",

keywords = "ADI-PEG20, ASS1, GLS, PHGDH, Warburg, arginine deiminase, argininosuccinate synthetase 1, glucose, glutaminase, glutamine, metabolism",

author = "Kremer, {Jeff C.} and {Van Tine}, {Brian A.}",

note = "Funding Information: Funding was received from CJ{\textquoteright}s Journey, The Sarcoma Foundation of America, a Sarcoma Alliance for Research and Collaboration (SARC) Career Development Award (to B.A.V.T.), and Polaris Pharmaceuticals (to B.A.V.T.). Publisher Copyright: {\textcopyright} 2017, {\textcopyright} 2017 Taylor & Francis Group, LLC.",

year = "2017",

month = may,

day = "4",

doi = "10.1080/23723556.2017.1295131",

language = "English",

volume = "4",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

number = "3",

}

TY - JOUR

T1 - Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

AU - Kremer, Jeff C.

AU - Van Tine, Brian A.

N1 - Funding Information: Funding was received from CJ’s Journey, The Sarcoma Foundation of America, a Sarcoma Alliance for Research and Collaboration (SARC) Career Development Award (to B.A.V.T.), and Polaris Pharmaceuticals (to B.A.V.T.). Publisher Copyright: © 2017, © 2017 Taylor & Francis Group, LLC.

PY - 2017/5/4

Y1 - 2017/5/4

N2 - Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously increasing glutamine metabolism via the tricarboxylic acid cycle. Simultaneous arginine deprivation and inhibition of the subsequent metabolic adaptations induce synthetic lethality.

AB - Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously increasing glutamine metabolism via the tricarboxylic acid cycle. Simultaneous arginine deprivation and inhibition of the subsequent metabolic adaptations induce synthetic lethality.

KW - ADI-PEG20

KW - ASS1

KW - GLS

KW - PHGDH

KW - Warburg

KW - arginine deiminase

KW - argininosuccinate synthetase 1

KW - glucose

KW - glutaminase

KW - glutamine

KW - metabolism

UR - http://www.scopus.com/inward/record.url?scp=85048599630&partnerID=8YFLogxK

U2 - 10.1080/23723556.2017.1295131

DO - 10.1080/23723556.2017.1295131

M3 - Article

C2 - 28616574

AN - SCOPUS:85048599630

SN - 2372-3556

VL - 4

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - e1295131

ER -

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this