Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

Jeff C. Kremer, Brian A. Van Tine

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously increasing glutamine metabolism via the tricarboxylic acid cycle. Simultaneous arginine deprivation and inhibition of the subsequent metabolic adaptations induce synthetic lethality.

Original languageEnglish
Article numbere1295131
JournalMolecular and Cellular Oncology
Volume4
Issue number3
DOIs
StatePublished - May 4 2017

Keywords

  • ADI-PEG20
  • ASS1
  • GLS
  • PHGDH
  • Warburg
  • arginine deiminase
  • argininosuccinate synthetase 1
  • glucose
  • glutaminase
  • glutamine
  • metabolism

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