TY - JOUR
T1 - Theory to predict shear stress on cells in turbulent blood flow
AU - Morshed, Khandakar Niaz
AU - Bark, David
AU - Forleo, Marcio
AU - Dasi, Lakshmi Prasad
N1 - Funding Information:
The authors gratefully acknowledge funding from National Institutes of Health (NIH) under Award Number R01HL119824, and the American Heart Association under award 11SDG5170011. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
PY - 2014/8/29
Y1 - 2014/8/29
N2 - Shear stress on blood cells and platelets transported in a turbulent flow dictates the fate and biological activity of these cells. We present a theoretical link between energy dissipation in turbulent flows to the shear stress that cells experience and show that for the case of physiological turbulent blood flow: (a) the Newtonian assumption is valid, (b) turbulent eddies are universal for the most complex of blood flow problems, and (c) shear stress distribution on turbulent blood flows is possibly universal. Further we resolve a long standing inconsistency in hemolysis between laminar and turbulent flow using the theoretical framework. This work demonstrates that energy dissipation as opposed to bulk shear stress in laminar or turbulent blood flow dictates local mechanical environment of blood cells and platelets universally.
AB - Shear stress on blood cells and platelets transported in a turbulent flow dictates the fate and biological activity of these cells. We present a theoretical link between energy dissipation in turbulent flows to the shear stress that cells experience and show that for the case of physiological turbulent blood flow: (a) the Newtonian assumption is valid, (b) turbulent eddies are universal for the most complex of blood flow problems, and (c) shear stress distribution on turbulent blood flows is possibly universal. Further we resolve a long standing inconsistency in hemolysis between laminar and turbulent flow using the theoretical framework. This work demonstrates that energy dissipation as opposed to bulk shear stress in laminar or turbulent blood flow dictates local mechanical environment of blood cells and platelets universally.
UR - http://www.scopus.com/inward/record.url?scp=84922357665&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0105357
DO - 10.1371/journal.pone.0105357
M3 - Article
C2 - 25171175
AN - SCOPUS:84922357665
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 8
M1 - e105357
ER -