Theory of NMR signal behavior in magnetically inhomogeneous tissues: The static dephasing regime

Dmitriy A. Yablonskiy, E. Mark Haacke

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This paper is devoted to a theory of the NMR signal behavior in biological tissues in the presence of static magnetic field inhomogeneities. We have developed an approach that analytically describes the NMR signal in the static dephasing regime where diffusion phenomena may be ignored. This approach has been applied to evaluate the NMR signal in the presence of a blood vessel network (with an application to functional imaging), bone marrow (for two specific trabecular structures, asymmetrical and columnar) and a ferrite contrast agent. All investigated systems have some common behavior. If the echo time TE is less than a known characteristic time tc for a given system, then the signal decays exponentially with an argument which depends quadratically on TE. This is equivalent to an R2* relaxation rate which is a linear function of TE. In the opposite case, when TE is greater than tc, the NMR signal follows a simple exponential decay and the relaxation rate does not depend on the echo time. For this time interval, R2* is a linear function of a) volume fraction ζ occupied by the field‐creating objects, b) magnetic field B0 or just the objects' magnetic moment for ferrite particles, and c) susceptibility difference Δχ between the objects and the medium.

Original languageEnglish
Pages (from-to)749-763
Number of pages15
JournalMagnetic resonance in medicine
Issue number6
StatePublished - Dec 1994


  • bone marrow
  • contrast agents
  • functional imaging
  • susceptibility effects


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