Theoretical and experimental approaches for studying factors defining the Helicobacter pylori-host relationship

Per G. Falk, Andrew J. Syder, Janaki L. Guruge, Denise Kirschner, Martin J. Blaser, Jeffrey I. Gordon

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Mathematical modeling has helped develop hypotheses about the role of microbial and host parameters in the initial and subsequent phases of Helicobacter pylori colonization. Transgenic mice have been used to test the hypothesis that the outcome of colonization is influenced by whether bacteria can adhere to available epithelial cell receptors. Complementary use of modeling and experimental approaches should facilitate studies of H. pylori pathogenesis. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalTrends in Microbiology
Volume8
Issue number7
DOIs
StatePublished - Jul 1 2000

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