The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes

Erik A. Feldmann; Paolo De Bona; Roberto Galletto

doi:10.1074/jbc.M115.637678

The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes

Erik A. Feldmann, Paolo De Bona, Roberto Galletto

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Rap1 is a general regulator of transcription and a component of the telomere. Results: Rap1 binds DNA in at least two binding modes. Conclusion: Access to binding modes in vitro is affected by different regions of the protein. Significance: The ability of Rap1 to access different binding modes may impact its functions.

Original language	English
Pages (from-to)	11455-11466
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M115.637678
State	Published - May 1 2015

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title = "The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes",

abstract = "Background: Rap1 is a general regulator of transcription and a component of the telomere. Results: Rap1 binds DNA in at least two binding modes. Conclusion: Access to binding modes in vitro is affected by different regions of the protein. Significance: The ability of Rap1 to access different binding modes may impact its functions.",

author = "Feldmann, \{Erik A.\} and \{De Bona\}, Paolo and Roberto Galletto",

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T1 - The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes

AU - Feldmann, Erik A.

AU - De Bona, Paolo

AU - Galletto, Roberto

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: Rap1 is a general regulator of transcription and a component of the telomere. Results: Rap1 binds DNA in at least two binding modes. Conclusion: Access to binding modes in vitro is affected by different regions of the protein. Significance: The ability of Rap1 to access different binding modes may impact its functions.

AB - Background: Rap1 is a general regulator of transcription and a component of the telomere. Results: Rap1 binds DNA in at least two binding modes. Conclusion: Access to binding modes in vitro is affected by different regions of the protein. Significance: The ability of Rap1 to access different binding modes may impact its functions.

UR - https://www.scopus.com/pages/publications/84929492277

U2 - 10.1074/jbc.M115.637678

DO - 10.1074/jbc.M115.637678

M3 - Article

C2 - 25805496

AN - SCOPUS:84929492277

SN - 0021-9258

VL - 290

SP - 11455

EP - 11466

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 18

ER -

The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes

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