The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes

Erik A. Feldmann; Paolo De Bona; Roberto Galletto

doi:10.1074/jbc.M115.637678

The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes

Erik A. Feldmann, Paolo De Bona, Roberto Galletto

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Rap1 is a general regulator of transcription and a component of the telomere. Results: Rap1 binds DNA in at least two binding modes. Conclusion: Access to binding modes in vitro is affected by different regions of the protein. Significance: The ability of Rap1 to access different binding modes may impact its functions.

Original language	English
Pages (from-to)	11455-11466
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M115.637678
State	Published - May 1 2015

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title = "The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes",

abstract = "Background: Rap1 is a general regulator of transcription and a component of the telomere. Results: Rap1 binds DNA in at least two binding modes. Conclusion: Access to binding modes in vitro is affected by different regions of the protein. Significance: The ability of Rap1 to access different binding modes may impact its functions.",

author = "Feldmann, {Erik A.} and {De Bona}, Paolo and Roberto Galletto",

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AU - Feldmann, Erik A.

AU - De Bona, Paolo

AU - Galletto, Roberto

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N2 - Background: Rap1 is a general regulator of transcription and a component of the telomere. Results: Rap1 binds DNA in at least two binding modes. Conclusion: Access to binding modes in vitro is affected by different regions of the protein. Significance: The ability of Rap1 to access different binding modes may impact its functions.

AB - Background: Rap1 is a general regulator of transcription and a component of the telomere. Results: Rap1 binds DNA in at least two binding modes. Conclusion: Access to binding modes in vitro is affected by different regions of the protein. Significance: The ability of Rap1 to access different binding modes may impact its functions.

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The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes

Abstract

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