The wide diversity and complexity of peptides bound to class II MHC molecules

Anish Suri, Scott B. Lovitch, Emil R. Unanue

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

The identification and quantitation of peptides selected by class II MHC molecules during natural processing of proteins is of key importance in understanding the repertoire and distribution of T cells. The examination of peptides selected by class II MHC molecules has depended greatly on mass spectrometry, a powerful technique that identifies and sequences peptides in complex mixtures with great sensitivity and precision. Such analysis has resulted in the identification of several factors, including the repertoire of peptides selected by MHC molecules during natural processing of proteins, motifs important for selection of processed peptides, conformational isomers of peptide-MHC complexes, and post-translational changes to the peptides.

Original languageEnglish
Pages (from-to)70-77
Number of pages8
JournalCurrent Opinion in Immunology
Volume18
Issue number1
DOIs
StatePublished - Feb 2006

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