The wavelength of light governing intraocular immune reactions

T. A. Ferguson, S. L. Mahendra, P. Hooper, H. J. Kaplan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Injection of antigen into the anterior chamber of the eye results in the induction of suppressed systemic cell-mediated responses as measured by delayed-type hypersensitivity or contact hypersensitivity (CHS). Previous studies from the authors' laboratories have determined that this response is governed by exposure of the eye to visible light during the initial intraocular encounter between T cells and antigen. To more fully understand the role of light, as well as to begin to understand the molecular mediators involved, the authors chose to explore the properties of light governing the effect. Neutral density filter were used to demonstrate that the minimum amount of light required to induce suppression of CHS following anterior chamber injection of antigen is 1-2 lux (lumens/meter2). With narrow band filters, the wavelengths responsible for suppression were shown to be 500-510 nm. The results show that the effect of light extends beyond the hapten- derivatized spleen cell system to other antigens placed in the anterior chamber of the eye. Studies also show that the retina and the pineal gland, two light absorbing structures, may not be involved. The results in this report show that light of very restricted wavelengths controls intraocular immune reactions.

Original languageEnglish
Pages (from-to)1788-1795
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume33
Issue number5
StatePublished - Jan 1 1992

Keywords

  • T cell
  • anterior chamber associated immune deviation
  • delayed-type hypersensitivity
  • immunoregulation
  • light

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