TY - JOUR
T1 - The wall-thinning to transmitral flow-velocity relation
T2 - Derivation with in vivo validation
AU - Cook, Danielle
AU - Sessoms, Mark
AU - Kovács, Sándor J.
N1 - Funding Information:
The authors appreciate the expertise of Peggy Brown in echocardiographic data acquisition. They are also thankful for helpful comments and criticisms by Andrew Bowman and Mustafa Karamanoglu in the preparation of the manuscript. This work was supported, in part, by the Whitaker Foundation (Roslyn, VA), the National Institutes of Health [HL54179, HL04023] (Bethesda, MD), and the Alan A. and Edith L. Wolff Charitable Trust (St Louis, MO).
PY - 2002
Y1 - 2002
N2 - Motion of the endocardial surface in diastole is the resultant effect of wall thinning. Endocardial wall motion to transmitral flow (Doppler E-wave) relations that predict wall thinning are derived using conservation of myocardial volume, two simplified (spatiotemporally homogeneous) left ventricular (LV) geometric models and the constant-volume pump attribute of the heart. For validation, model-predicted vs. color M-mode recorded maximum rate of wall thinning was compared in (n = 15) normal controls. Excellent agreement for both models (r = 0.84, r = 0.86) was observed. For abnormal LV function (n = 15), model-predicted vs. M-mode recorded maximum rate of wall-thinning correlated poorly (r = -0.28, r = -0.22). We conclude that, in normal ventricles, the Doppler E-wave and wall thinning are related through the constant-volume attribute of the heart and its geometry. Pathologic cases are governed by the same principles, but the filling to wall-thinning relation is altered by spatiotemporal inhomogeneities in geometry and wall motion.
AB - Motion of the endocardial surface in diastole is the resultant effect of wall thinning. Endocardial wall motion to transmitral flow (Doppler E-wave) relations that predict wall thinning are derived using conservation of myocardial volume, two simplified (spatiotemporally homogeneous) left ventricular (LV) geometric models and the constant-volume pump attribute of the heart. For validation, model-predicted vs. color M-mode recorded maximum rate of wall thinning was compared in (n = 15) normal controls. Excellent agreement for both models (r = 0.84, r = 0.86) was observed. For abnormal LV function (n = 15), model-predicted vs. M-mode recorded maximum rate of wall-thinning correlated poorly (r = -0.28, r = -0.22). We conclude that, in normal ventricles, the Doppler E-wave and wall thinning are related through the constant-volume attribute of the heart and its geometry. Pathologic cases are governed by the same principles, but the filling to wall-thinning relation is altered by spatiotemporal inhomogeneities in geometry and wall motion.
KW - Diastolic function
KW - Doppler echocardiography
KW - Mathematical modeling
UR - http://www.scopus.com/inward/record.url?scp=0036020085&partnerID=8YFLogxK
U2 - 10.1016/S0301-5629(02)00524-0
DO - 10.1016/S0301-5629(02)00524-0
M3 - Article
C2 - 12113787
AN - SCOPUS:0036020085
SN - 0301-5629
VL - 28
SP - 745
EP - 755
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 6
ER -