The vortex formation time to diastolic function relation: Assessment of pseudonormalized versus normal filling

In early diastole, the suction pump feature of the left ventricle opens the mitral valve and aspirates atrial blood. The ventricle fills via a blunt profiled cylindrical jet of blood that forms an asymmetric toroidal vortex ring inside the ventricle whose growth has been quantified by the standard (dimensionless) expression for vortex formation time, VFT_standard = {transmitral velocity time integral}/ {mitral orifice diameter}. It can differentiate between hearts having distinguishable early transmitral (Doppler E-wave) filling patterns. An alternative validated expression, VFT_kinematic reexpresses VFT_standard by incorporating left heart, near “constant-volume pump” physiology thereby revealing VFT_kinematic’s explicit dependence on maximum rate of longitudinal chamber expansion (E′). In this work, we show that VFT_kinematic can differentiate between hearts having indistinguishable E-wave patterns, such as pseudonormal (PN; 0.75 < E/A < 1.5 and E/E′ > 8) versus normal. Thirteen age-matched normal and 12 PN data sets (738 total cardiac cycles), all having normal LVEF, were selected from our Cardiovascular Biophysics Laboratory database. Doppler E-, lateral annular E′-waves, and M-mode data (mitral leaflet separation, chamber dimension) was used to compute VFT_standard and VFT_kinematic. VFT_standard did not differentiate between groups (normal [3.58 ± 1.06] vs. PN [4.18 ± 0.79], P = 0.13). In comparison, VFT_kinematic for normal (3.15 ± 1.28) versus PN (4.75 ± 1.35) yielded P = 0.006. Hence, the applicability of VFT_kinematic for diastolic function quantitation has been broadened to include analysis of PN filling patterns in age-matched groups.