TY - JOUR
T1 - The virome in mammalian physiology and disease
AU - Virgin, Herbert W.
N1 - Funding Information:
H.W.V. is supported by NIH grants AI054483, U54 AI057160, AI084887, and OD011170, Crohn’s and Colitis Foundation grants 3132 and 274415, and grant IBD-0357 from the Broad Medical Foundation.
PY - 2014/3/27
Y1 - 2014/3/27
N2 - The virome contains the most abundant and fastest mutating genetic elements on Earth. The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect the broad array of other types of organisms that inhabit us. Virome interactions with the host cannot be encompassed by a monotheistic view of viruses as pathogens. Instead, the genetic and transcriptional identity of mammals is defined in part by our coevolved virome, a concept with profound implications for understanding health and disease.
AB - The virome contains the most abundant and fastest mutating genetic elements on Earth. The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect the broad array of other types of organisms that inhabit us. Virome interactions with the host cannot be encompassed by a monotheistic view of viruses as pathogens. Instead, the genetic and transcriptional identity of mammals is defined in part by our coevolved virome, a concept with profound implications for understanding health and disease.
UR - http://www.scopus.com/inward/record.url?scp=84897127283&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2014.02.032
DO - 10.1016/j.cell.2014.02.032
M3 - Review article
C2 - 24679532
AN - SCOPUS:84897127283
SN - 0092-8674
VL - 157
SP - 142
EP - 150
JO - Cell
JF - Cell
IS - 1
ER -