The virome in mammalian physiology and disease

Herbert W. Virgin

doi:10.1016/j.cell.2014.02.032

The virome in mammalian physiology and disease

Herbert W. Virgin

Immunobiology

Research output: Contribution to journal › Review article › peer-review

287 Scopus citations

Abstract

The virome contains the most abundant and fastest mutating genetic elements on Earth. The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect the broad array of other types of organisms that inhabit us. Virome interactions with the host cannot be encompassed by a monotheistic view of viruses as pathogens. Instead, the genetic and transcriptional identity of mammals is defined in part by our coevolved virome, a concept with profound implications for understanding health and disease.

Original language	English
Pages (from-to)	142-150
Number of pages	9
Journal	Cell
Volume	157
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2014.02.032
State	Published - Mar 27 2014

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