The VCP/p97 system at a glance: Connecting cellular function to disease pathogenesis

Hemmo Meyer, Conrad C. Weihl

Research output: Contribution to journalArticlepeer-review

190 Scopus citations

Abstract

The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important element of the ubiquitin system. Together with a network of cofactors, it regulates an ever-expanding range of processes that stretch into almost every aspect of cellular physiology. Its main role in proteostasis and key functions in signaling pathways are of relevance to degenerative diseases and genomic stability. In this Cell Science at a Glance and the accompanying poster, we give a brief overview of this complex system. In addition, we discuss the pathogenic basis for VCP/p97-associated diseases and then highlight in more detail new exciting links to the translational stress response and RNA biology that further underscore the significance of the VCP/p97 system.

Original languageEnglish
Pages (from-to)3877-3883
Number of pages7
JournalJournal of cell science
Volume127
Issue number18
DOIs
StatePublished - 2014

Keywords

  • ALS
  • Cdc48
  • IBMPFD
  • Ubiquitin
  • VCP
  • p97

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