The validation of freely diffusible tracer methods with NMR detection for measurement of blood flow

While the general theory of measuring organ perfusion using exogenously administered freely diffusible tracers was originally formulated over 40 years ago, the application of NMR techniques for tracer detection is a recent development. A brief theoretical review and discussion of the literature validating the use of deuterium and fluorine as NMR‐detectable tracers is provided. © 1991 Academic Press, Inc.