The Utility of Intraindividual Variability in Selective Attention Tasks as an Early Marker for Alzheimer's Disease

Janet M. Duchek, David A. Balota, Chi Shing Tse, David M. Holtzman, Anne M. Fagan, Alison M. Goate

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

This study explored differences in intraindividual variability in 3 attention tasks across a large sample of healthy older adults and individuals with very mild dementia of the Alzheimer's type (DAT). Three groups of participants (healthy young adults, healthy older adults, very mild DAT) were administered 3 experimental measures of attentional selection and switching (Stroop, Simon, task switching). The results indicated that a measure of intraindividual variability, coefficient of variation (CoV; SD/M), increased across age and early stage DAT. The CoV in Stroop discriminated the performance of ε{lunate}4 carriers from noncarriers in healthy older controls and the CoV in task switching was correlated with cerebrospinal fluid (CSF) biomarkers predictive of DAT.

Original languageEnglish
Pages (from-to)746-758
Number of pages13
JournalNeuropsychology
Volume23
Issue number6
DOIs
StatePublished - Nov 2009

Keywords

  • Alzheimer's disease
  • aging
  • attention
  • intraindividual variation

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