The use of warfarin for dvt prophylaxis following hip and knee arthroplasty: How often are patients within their target INR range?

Denis Nam, Anita Sadhu, Jeffrey Hirsh, James A. Keeney, Ryan M. Nunley, Robert L. Barrack

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The purpose of this study was to determine the percentage of time that patients are therapeutic when prescribed warfarin for chemical thromboprophylaxis following a hip or knee arthroplasty procedure. One hundred eighty-four patients receiving warfarin for 4. weeks postoperatively, dosed using a Web-application accounting for patient demographics, INR levels, and concomitant medication use, were included. Patients with a target INR range between 1.7 and 2.7 were therapeutic for only 54.4% of the time (32.5% subtherapeutic, 13.0% supratherapeutic) while patients with a target INR range between 2.0 and 3.0 were therapeutic for only 45.9% of the time (39.2% subtherapeutic, 14.8% supratherapeutic). Patients receiving warfarin for chemical thromboprophylaxis are within their targeted INR range for only a limited period of time during their postoperative course.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalJournal of Arthroplasty
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Coumadin
  • Thromboprophylaxis
  • Total knee arthroplasty
  • Venous thromboembolism
  • Warfarin

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