The use of hyperventilation and its impact on cerebral ischemia in the treatment of traumatic brain injury

K. D. Yundt, M. N. Diringer

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Traumatic brain injury is a common occurrence in the United States, leading to approximately 190,000 deaths or long-term disabilities. Following the primary insult, secondary disturbances in cerebral blood flow (CBF) and metabolism may have deleterious effects on potentially viable neurons. Recent studies evaluating CBF immediately following head injury have revealed flows low enough to produce cerebral ischemia. Hyperventilation is used routinely to lower suspected increased intracranial pressure (ICP). Aggressive hyperventilation produces a marked reduction in CBF, which may give rise to or exacerbate cerebral ischemia, thus enhancing rather than reducing secondary injury. This article reviews the role of hyperventilation in the treatment of increased ICP and its impact on cerebral ischemia following traumatic brain injury.

Original languageEnglish
Pages (from-to)163-184
Number of pages22
JournalCritical Care Clinics
Volume13
Issue number1
DOIs
StatePublished - 1997

Fingerprint

Dive into the research topics of 'The use of hyperventilation and its impact on cerebral ischemia in the treatment of traumatic brain injury'. Together they form a unique fingerprint.

Cite this