@article{fa9765df17234b469f201ecc60a157c8,
title = "The use of HMQC-TOCSY experiments for elucidating the structures of bicyclic lactams: Uncovering a surprise rearrangement in the synthesis of a key prophe building block",
abstract = "HMQC-TOCSY experiments were used to unequivocally assign the ring skeletons of several bicyclic lactams. This work demonstrated the power of these techniques for establishing the complete carbon connectivity of peptide building blocks with closely overlapping protons. In addition, it has led to the discovery of a surprise rearrangement reaction and allowed for the correction of a previously misassigned Pro-Phe building block ring skeleton.",
author = "Moeller, {Kevin D.} and Hanau, {Cathleen E.} and Andr{\`e} d'Avignon",
note = "Funding Information: AcknowledgmentsW: e thank the National Instituteso f Health (PO1 GM24483-12),t he National Science Foundation (CHE-9023698),a nd WashingtonU niversity for their generous support of our programs. CathleenH anau thanksM onsantofor a graduates tudentf ellowship.W e also gratefully acknowledgeth e WashingtonU niversity High Resolution NMR Facility, partially supported by NIH grants RRO2tXl4, RRO5018,a nd RR07155, and the WashingtonU niversity Mass SpectrometryR esource Center, partially supportedb y NJHRROO954,f or their assistance.",
year = "1994",
doi = "10.1016/S0040-4039(00)75973-9",
language = "English",
volume = "35",
pages = "825--828",
journal = "Tetrahedron Letters",
issn = "0040-4039",
number = "6",
}