Neurotrophins rely on Trk tyrosine kinase and p75 receptors for signal transduction. Recently, other roles for these receptors have been identified. Many questions have been raised about the mechanism by which these receptors mediate diverse cellular functions. Studies indicate a great deal of neurotrophin signaling specificity may stem from ligand-receptor selectivity and intracellular protein recruitment.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1 2001


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