The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins

Keyphrases

• Cellular Proteins 100%
• Stress-induced 100%
• Lysosomal Degradation 100%
• Long-lived Proteins 100%
• Ubiquitin-activating Enzyme E1 100%
• Mutant Cells 75%
• Degradation Rate 75%
• Intracellular Protein 50%
• Heat-induced 50%
• Ubiquitin System 50%
• Thermolabile 50%
• Autophagic Vacuoles 50%
• Accelerated Degradation 50%
• Vacuole 25%
• Fold Increase 25%
• Autophagosome 25%
• High Temperature 25%
• 4-fold 25%
• Cycloheximide 25%
• Ubiquitin 25%
• Proteolysis 25%
• Chloroquine 25%
• Starvation 25%
• Ammonium Chloride 25%
• Heat Stress 25%
• 3-methyladenine (3-MA) 25%
• In the Wild 25%
• Basal Rate 25%
• Short-lived Protein 25%
• Enhanced Degradation 25%
• FM3A 25%

Biochemistry, Genetics and Molecular Biology

• Wild Type 100%
• Cell Mutant 100%
• Ubiquitin 100%
• Ubiquitin-Conjugating Enzyme 100%
• Cycloheximide 33%
• Heat Stress 33%
• Proteolysis 33%

Immunology and Microbiology

• Ubiquitins 100%
• Wild Type 60%
• Cell Mutant 60%
• Cell Line 40%
• Protein Degradation 20%
• Heat Stress 20%
• Chloroquine 20%