The tyrosine kinase adaptor protein FRS2 is oncogenic and amplified in high-grade serous ovarian cancer

Leo Y. Luo, Eejung Kim, Hiu Wing Cheung, Barbara A. Weir, Gavin P. Dunn, Rhine R. Shen, William C. Hahn

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

High-grade serous ovarian cancers (HGSOC) are characterized by widespread recurrent regions of copy-number gain and loss. Here, we interrogated 50 genes that are recurrently amplified in HGSOC and essential for cancer proliferation and survival in ovarian cancer cell lines. FRS2 is one of the 50 genes located on chromosomal region 12q15 that is focally amplified in 12.5% of HGSOC. We found that FRS2-amplified cancer cell lines are dependent on FRS2 expression, and that FRS2 overexpression in immortalized human cell lines conferred the ability to grow in an anchorage-independent manner and as tumors in immunodeficient mice. FRS2, an adaptor protein in the FGFR pathway, induces downstream activation of the Ras-MAPK pathway. These observations identify FRS2 as an oncogene in a subset of HGSOC that harbor FRS2 amplifications.

Original languageEnglish
Pages (from-to)502-509
Number of pages8
JournalMolecular Cancer Research
Volume13
Issue number3
DOIs
StatePublished - Mar 1 2015

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