@article{ed4f4d126cb74f0e9ea3eb941c484f1e,
title = "The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits",
abstract = "Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is a public resource of genetic datasets and genomic annotations dedicated to type 2 diabetes (T2D) and related traits. Here, we seek to make the T2DKP more accessible to prospective users and more useful to existing users. First, we evaluate the T2DKP's comprehensiveness by comparing its datasets with those of other repositories. Second, we describe how researchers unfamiliar with human genetic data can begin using and correctly interpreting them via the T2DKP. Third, we describe how existing users can extend their current workflows to use the full suite of tools offered by the T2DKP. We finally discuss the lessons offered by the T2DKP toward the goal of democratizing access to complex disease genetic results.",
keywords = "CMDKP, GWAS, T2DKP, data sharing, diabetes, effector genes, genetic associations, genetic support, genomics, portal",
author = "{AMP-T2D Consortium} and Costanzo, {Maria C.} and {von Grotthuss}, Marcin and Jeffrey Massung and Dongkeun Jang and Lizz Caulkins and Ryan Koesterer and Clint Gilbert and Welch, {Ryan P.} and Parul Kudtarkar and Quy Hoang and Boughton, {Andrew P.} and Preeti Singh and Ying Sun and Marc Duby and Annie Moriondo and Trang Nguyen and Patrick Smadbeck and Alexander, {Benjamin R.} and MacKenzie Brandes and Mary Carmichael and Peter Dornbos and Todd Green and Huellas-Bruskiewicz, {Kenneth C.} and Yue Ji and Alexandria Kluge and McMahon, {Aoife C.} and Mercader, {Josep M.} and Oliver Ruebenacker and Sebanti Sengupta and Dylan Spalding and Daniel Taliun and Beena Akolkar and Allred, {Nicholette D.} and David Altshuler and Below, {Jennifer E.} and Richard Bergman and Beulens, {Joline W.J.} and John Blangero and Michael Boehnke and Krister Bokvist and Erwin Bottinger and Donald Bowden and Brosnan, {M. Julia} and Christopher Brown and Kenneth Bruskiewicz and Burtt, {No{\"e}l P.} and In{\^e}s Cebola and John Chambers and {Ida Chen}, {Yii Der} and Andriy Cherkas and Chu, {Audrey Y.} and Christopher Clark and Melina Claussnitzer and Cox, {Nancy J.} and Hoed, {Marcel den} and Duc Dong and Ravindranath Duggirala and Jos{\'e}e Dupuis and Elders, {Petra J.M.} and Engreitz, {Jesse M.} and Eric Fauman and Jorge Ferrer and Jason Flannick and Paul Flicek and Matthew Flickinger and Florez, {Jose C.} and Fox, {Caroline S.} and Frayling, {Timothy M.} and Frazer, {Kelly A.} and Gaulton, {Kyle J.} and Gloyn, {Anna L.} and Hanis, {Craig L.} and Robert Hanson and Hattersley, {Andrew T.} and Im, {Hae Kyung} and Sidra Iqbal and Jacobs, {Suzanne B.R.} and Jang, {Dong Keun} and Tad Jordan and Tania Kamphaus and Fredrik Karpe and Keane, {Thomas M.} and Kim, {Seung K.} and Kasper Lage and Lange, {Leslie A.} and Mitchell Lazar and Donna Lehman and Liu, {Ching Ti} and Loos, {Ruth J.F.} and Ma, {Ronald Ching wan} and Patrick MacDonald and Maurano, {Matthew T.} and McCarthy, {Mark I.} and Gil McVean and Meigs, {James B.} and Miller, {Melissa R.} and Braxton Mitchell and Mohlke, {Karen L.} and Samuel Morabito and Claire Morgan and Shannon Mullican and Sharvari Narendra and Ng, {Maggie C.Y.} and Lynette Nguyen and Palmer, {Colin N.A.} and Parker, {Stephen C.J.} and Antonio Parrado and Afshin Parsa and Pawlyk, {Aaron C.} and Pearson, {Ewan R.} and Andrew Plump and Michael Province and Thomas Quertermous and Susan Redline and Reilly, {Dermot F.} and Bing Ren and Rich, {Stephen S.} and Richards, {J. Brent} and Rotter, {Jerome I.} and Hartmut Ruetten and Salem, {Rany M.} and Maike Sander and Michael Sanders and Dharambir Sanghera and Scott, {Laura J.} and David Siedzik and Xueling Sim and Robert Sladek and Kerrin Small and Philip Smith and Peter Stein and Stringham, {Heather M.} and Katalin Susztak and {{\textquoteright}t Hart}, {Leen M.} and Kent Taylor and Thomas, {Melissa K.} and Todd, {Jennifer A.} and Udler, {Miriam S.} and Benjamin Voight and Andre Wan and David Wholley and Kaan Yuksel and Zaghloul, {Norann A.} and Fauman, {Eric B.} and Kamphaus, {Tania Nayak} and Abecasis, {Gon{\c c}alo R.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
month = apr,
day = "4",
doi = "10.1016/j.cmet.2023.03.001",
language = "English",
volume = "35",
pages = "695--710.e6",
journal = "Cell metabolism",
issn = "1550-4131",
number = "4",
}