TY - JOUR
T1 - The Tropism of Pleiotrophin
T2 - Orchestrating Glioma Brain Invasion
AU - Gutmann, David H.
N1 - Funding Information:
D.H.G. is supported by a Research Program Award from the National Institute of Neurological Disorders and Stroke ( 1-R35-NS097211-01 ).
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/8/24
Y1 - 2017/8/24
N2 - The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.
AB - The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.
UR - http://www.scopus.com/inward/record.url?scp=85028378518&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2017.08.011
DO - 10.1016/j.cell.2017.08.011
M3 - Short survey
C2 - 28841413
AN - SCOPUS:85028378518
SN - 0092-8674
VL - 170
SP - 821
EP - 822
JO - Cell
JF - Cell
IS - 5
ER -