The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.

Original languageEnglish
Pages (from-to)821-822
Number of pages2
JournalCell
Volume170
Issue number5
DOIs
StatePublished - Aug 24 2017

Fingerprint Dive into the research topics of 'The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion'. Together they form a unique fingerprint.

Cite this