The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.

Original languageEnglish
Pages (from-to)821-822
Number of pages2
Issue number5
StatePublished - Aug 24 2017

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