The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion

David H. Gutmann

doi:10.1016/j.cell.2017.08.011

The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion

David H. Gutmann

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.

Original language	English
Pages (from-to)	821-822
Number of pages	2
Journal	Cell
Volume	170
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2017.08.011
State	Published - Aug 24 2017

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title = "The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion",

abstract = "The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.",

author = "Gutmann, {David H.}",

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AU - Gutmann, David H.

PY - 2017/8/24

Y1 - 2017/8/24

N2 - The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.

AB - The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.

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DO - 10.1016/j.cell.2017.08.011

M3 - Short survey

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AN - SCOPUS:85028378518

SN - 0092-8674

VL - 170

SP - 821

EP - 822

JO - Cell

JF - Cell

IS - 5

ER -

The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion

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