@article{1348419489074a6b8171b3dce44f4ee4,
title = "The trend of disruption in the functional brain network topology of Alzheimer{\textquoteright}s disease",
abstract = "Alzheimer{\textquoteright}s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain{\textquoteright}s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have examined different stages of AD from a complex network perspective that cover different topological scales. This study used resting state fMRI data to analyze the trend of functional connectivity alterations from a cognitively normal (CN) state through early and late mild cognitive impairment (EMCI and LMCI) and to Alzheimer{\textquoteright}s disease. The analyses had been done at the local (hubs and activated links and areas), meso (clustering, assortativity, and rich-club), and global (small-world, small-worldness, and efficiency) topological scales. The results showed that the trends of changes in the topological architecture of the functional brain network were not entirely proportional to the AD progression. There were network characteristics that have changed non-linearly regarding the disease progression, especially at the earliest stage of the disease, i.e., EMCI. Further, it has been indicated that the diseased groups engaged somatomotor, frontoparietal, and default mode modules compared to the CN group. The diseased groups also shifted the functional network towards more random architecture. In the end, the methods introduced in this paper enable us to gain an extensive understanding of the pathological changes of the AD process.",
author = "{for the Alzheimer's Disease Neuroimaging Initiative} and Alireza Fathian and Yousef Jamali and Raoufy, {Mohammad Reza} and Weiner, {Michael W.} and Norbert Schuf and Rosen, {Howard J.} and Miller, {Bruce L.} and Thomas Neylan and Jacqueline Hayes and Shannon Finley and Paul Aisen and Zaven Khachaturian and Thomas, {Ronald G.} and Michael Donohue and Sarah Walter and Devon Gessert and Tamie Sather and Gus Jiminez and Leon Thal and James Brewer and Helen Vanderswag and Adam Fleisher and Melissa Davis and Rosemary Morrison and Ronald Petersen and Jack, {Cliford R.} and Matthew Bernstein and Bret Borowski and Jef Gunter and Matt Senjem and Prashanthi Vemuri and David Jones and Kejal Kantarci and Chad Ward and Mason, {Sara S.} and Albers, {Colleen S.} and David Knopman and Kris Johnson and William Jagust and Susan Landau and Trojanowki, {John Q.} and Shaw, {Leslie M.} and Virginia Lee and Magdalena Korecka and Michal Figurski and Arnold, {Steven E.} and Karlawish, {Jason H.} and David Wolk and Toga, {Arthur W.} and Karen Crawford and Scott Neu and Schneider, {Lon S.} and Sonia Pawluczyk and Mauricio Beccera and Liberty Teodoro and Spann, {Bryan M.} and Laurel Beckett and Danielle Harvey and Evan Fletcher and Owen Carmichael and John Olichney and Charles DeCarli and Green, {Robert C.} and Sperling, {Reisa A.} and Johnson, {Keith A.} and Gad Marshall and Meghan Frey and Barton Lane and Allyson Rosen and Jared Tinklenberg and Saykin, {Andrew J.} and Foroud, {Tatiana M.} and Li Shen and Kelley Faber and Sungeun Kim and Kwangsik Nho and Farlow, {Martin R.} and Hake, {Ann Marie} and Matthews, {Brandy R.} and Scott Herring and Cynthia Hunt and John Morris and Marc Raichle and Davie Holtzman and Cairns, {Nigel J.} and Erin Householder and Lisa Taylor-Reinwald and Beau Ances and Maria Carroll and Sue Leon and Mintun, {Mark A.} and Stacy Schneider and Angela Oliver and Lisa Raudin and Greg Sorensen and Lew Kuller and Chet Mathis and Lopez, {Oscar L.} and Oakley, {Mary Ann} and Steven Paul and Norman Relkin and Gloria Chaing and Lisa Raudin and Peter Davies and Howard Fillit and Franz Hefti and Mesulam, {M. Marcel} and Diana Kerwin and Mesulam, {Marek Marsel} and Kristine Lipowski and Wu, {Chuang Kuo} and Nancy Johnson and Jordan Grafman and William Potter and Peter Snyder and Adam Schwartz and Tom Montine and Peskind, {Elaine R.} and Nick Fox and Paul Thompson and Liana Apostolova and Kathleen Tingus and Ellen Woo and Silverman, {Daniel H.S.} and Lu, {Po H.} and George Bartzokis and Koeppe, {Robert A.} and Heidebrink, {Judith L.} and Lord, {Joanne L.} and Potkin, {Steven G.} and Adrian Preda and Dana Nguyenv and Norm Foster and Reiman, {Eric M.} and Kewei Chen and Adam Fleisher and Pierre Tariot and Stephanie Reeder and Steven Potkin and Mulnard, {Ruth A.} and Gaby Thai and Catherine Mc-Adams-Ortiz and Neil Buckholtz and John Hsiao and Marylyn Albert and Marilyn Albert and Chiadi Onyike and Daniel D{\textquoteright}Agostino and Stephanie Kielb and Simpson, {Donna M.} and Richard Frank and Jefrey Kaye and Joseph Quinn and Betty Lind and Raina Carter and Sara Dolen and Doody, {Rachelle S.} and Javier Villanueva-Meyer and Munir Chowdhury and Susan Rountree and Mimi Dang and Yaakov Stern and Honig, {Lawrence S.} and Bell, {Karen L.} and Daniel Marson and Randall Grifth and David Clark and David Geldmacher and John Brockington and Erik Roberson and Hillel Grossman and Efe Mitsis and {de Toledo-Morrell}, Leyla and Shah, {Raj C.} and Debra Fleischman and Konstantinos Arfanakis and Ranjan Duara and Daniel Varon and Greig, {Maria T.} and Peggy Roberts and Galvin, {James E.} and Brittany Cerbone and Michel, {Christina A.} and Henry Rusinek and {de Leon}, {Mony J.} and Lidia Glodzik and {De Santi}, Susan and Doraiswamy, {P. Murali} and Petrella, {Jefrey R.} and Wong, {Terence Z.} and Olga James and Smith, {Charles D.} and Greg Jicha and Peter Hardy and Partha Sinha and Elizabeth Oates and Gary Conrad and Porsteinsson, {Anton P.} and Goldstein, {Bonnie S.} and Kyle Womack",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41598-022-18987-y",
language = "English",
volume = "12",
journal = "Scientific reports",
issn = "2045-2322",
number = "1",
}