Abstract

TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.

Original languageEnglish
Pages (from-to)1266-1273
Number of pages8
JournalNature immunology
Volume7
Issue number12
DOIs
StatePublished - Dec 1 2006

Fingerprint

Dive into the research topics of 'The TREM receptor family and signal integration'. Together they form a unique fingerprint.

Cite this