The TREM receptor family and signal integration

Julia Klesney-Tait; Isaiah R. Turnbull; Marco Colonna

doi:10.1038/ni1411

The TREM receptor family and signal integration

Julia Klesney-Tait, Isaiah R. Turnbull, Marco Colonna

Research output: Contribution to journal › Review article › peer-review

475 Scopus citations

Abstract

TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.

Original language	English
Pages (from-to)	1266-1273
Number of pages	8
Journal	Nature immunology
Volume	7
Issue number	12
DOIs	https://doi.org/10.1038/ni1411
State	Published - Dec 2006

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abstract = "TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.",

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The TREM receptor family and signal integration

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