Effective tissue repair results from a rapid, temporally orchestrated series of events. At the site of local tissue injury, the production of many growth factors and cytokines is, in part, stimulated by the early growth response transcription factors such as Egr-1. Egr-1 protein binds to a family of corepressor proteins called NAB which function to block or limit Egr-1 trans-activation of cognate target genes. NAB2 blocks Egr-1 activation of the tissue factor (TF) promoter, Egr-1 stimulated production of PDGF-AB, HGF, TGFβ, and VEGF and the endogenous expression of PDGF-AB and TGFβ. Expression of a wild-type NAB2 but not a dominant negative NAB2 mutant abrogates Egr-1 driven TF promoter activity and tubule formation in an in vitro model of angiogenesis. These findings may have importance in any tissue that is subject to scarring after acute or chronic injury.

Original languageEnglish
Pages (from-to)480-486
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - 2001


  • Angiogenesis
  • Egr-1
  • Gene therapy
  • Growth factor
  • NAB2
  • Tissue repair
  • Transcriptional repressor


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