The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance

Biochemistry, Genetics and Molecular Biology

• Adaptive Response 33%
• Breed 33%
• Free Fatty Acids 33%
• Gene Expression 33%
• Glucose 33%
• Insulin 100%
• Insulin Resistance 100%
• Mitochondrial Biogenesis 33%
• Mitochondrial Volume Density 33%
• Mouse Model 33%
• Nuclear Receptor 33%
• Ob/Ob Mouse 33%
• Peroxisome Proliferator Activated Receptor Gamma Coactivator 1alpha 33%
• Peroxisome Proliferator-Activated Receptor 66%
• Respiratory Function 33%
• Small Hairpin RNA 33%
• Small Interfering RNA 33%
• Transcription Factors 33%
• Upregulation 33%
• Wild Type 100%

Keyphrases

• Adaptive Response 6%
• Cardiac Mitochondrial Function 100%
• Coactivator 100%
• Free Fatty Acids 6%
• Gene Expression 6%
• Glucose Intolerance 6%
• H9c2 6%
• High-fat Feeding 13%
• Insulin Resistance 100%
• Knockdown 6%
• Mitochondrial Biogenesis 6%
• Mitochondrial Density 6%
• Mitochondrial Respiratory Function 13%
• Mouse Model 6%
• Myotubes 6%
• Non-cell Autonomous 6%
• Nuclear Receptor 6%
• Oleate 6%
• Peroxisome Proliferator-activated Receptor-γ coactivator-1α (PGC-1α) 6%
• Proliferator-activated Receptor-γ 100%
• Short Hairpin RNA (shRNA) 6%
• Standard Chow 6%
• Transcription Factor 6%
• Transcriptional Repressor 100%
• Type Control 6%
• α Gene 6%