@article{4bcdfe176fce4a8ea2c6ce81a5a2166d,
title = "The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality",
abstract = "The molecular regulation of CD8+ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy.",
keywords = "Bhlhe40, PD-L1, Tubastatin A, acetate, epigenetic, metabolism, mitochondria, tissue resident memory T cell, tumor-infiltrating lymphocytes",
author = "Chaofan Li and Bibo Zhu and Son, {Young Min} and Zheng Wang and Li Jiang and Min Xiang and Zhenqing Ye and Beckermann, {Kathryn E.} and Yue Wu and Jenkins, {James W.} and Siska, {Peter J.} and Vincent, {Benjamin G.} and Prakash, {Y. S.} and Tobias Peikert and Edelson, {Brian T.} and Reshma Taneja and Kaplan, {Mark H.} and Rathmell, {Jeffrey C.} and Haidong Dong and Taro Hitosugi and Jie Sun",
note = "Funding Information: We thank the NIH tetramer core for the tetramers and H. Zhang for the scRNA-seq analysis. This study was funded by the NIH R01 AI112844, R01 AG047156, and R01 HL126647 (to J.S.); R01 HL056470 and R01 HL126451 (to P.K.S.); R01 AI057459 (to M.H.K.); R01 CA217987 (to J.C.R.); and R01 AI113118 and R01 AI132653 (to B.T.E.). K.E.B. receives funding from the Merck-Cancer Research Institute Irvington post-doctoral fellowship. P.J.S. is supported by the Else Kr?ner-Fresenius-Stiftung Foundation. C.L. performed the experiments, analyzed the data, and wrote the manuscript. Y.M.S. B.Z. Z.W. L.J. M.X. and J.W.J. assisted with the experiments. K.E.B. P.Y.S. T.P. P.J.S. B.G.V. B.T.E. R.T. T.H. M.H.K. J.C.R. and H.D. provided reagents and advice. J.S. supervised the project, designed the experiments, and wrote the manuscript. The authors declare no competing interests. Funding Information: We thank the NIH tetramer core for the tetramers and H. Zhang for the scRNA-seq analysis. This study was funded by the NIH R 0 1 AI112844 , R 0 1 AG047156 , and R 0 1 HL126647 (to J.S.); R01 HL056470 and R 0 1 HL126451 (to P.K.S.); R01 AI057459 (to M.H.K.); R01 CA217987 (to J.C.R.); and R01 AI113118 and R01 AI132653 (to B.T.E.). K.E.B. receives funding from the Merck-Cancer Research Institute Irvington post-doctoral fellowship . P.J.S. is supported by the Else Kr{\"o}ner-Fresenius-Stiftung Foundation . Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = sep,
day = "17",
doi = "10.1016/j.immuni.2019.08.013",
language = "English",
volume = "51",
pages = "491--507.e7",
journal = "Immunity",
issn = "1074-7613",
number = "3",
}