TY - JOUR
T1 - The tissue diagnostic instrument
AU - Hansma, Paul
AU - Yu, Hongmei
AU - Schultz, David
AU - Rodriguez, Azucena
AU - Yurtsev, Eugene A.
AU - Orr, Jessica
AU - Tang, Simon
AU - Miller, Jon
AU - Wallace, Joseph
AU - Zok, Frank
AU - Li, Cheng
AU - Souza, Richard
AU - Proctor, Alexander
AU - Brimer, Davis
AU - Nogues-Solan, Xavier
AU - Mellbovsky, Leonardo
AU - Pea, M. Jesus
AU - Diez-Ferrer, Oriol
AU - Mathews, Phillip
AU - Randall, Connor
AU - Kuo, Alfred
AU - Chen, Carol
AU - Peters, Mathilde
AU - Kohn, David
AU - Buckley, Jenni
AU - Li, Xiaojuan
AU - Pruitt, Lisa
AU - Diez-Perez, Adolfo
AU - Alliston, Tamara
AU - Weaver, Valerie
AU - Lotz, Jeffrey
N1 - Funding Information:
We thank the NIH for support of this work under Grant Nos. RO1 GM 065354 and RO1 AR 049770 and NIH Grant No. AR049770, the DOD under Grant No. W81XWH-05-1-330, and the Fondo de Investigaciones Sanitarias (FIS) under Grant No. PI07/90912. We thank Angus Scrimgeour for asking us to do indentation measurements on bone, Robert Recker for encouraging us to plan for clinical trials even when the BDI was at an early stage of development, Paul Zaslansky for pointing us toward dental applications, and Georg Fantner, Jonathan Adams, Patricia Turner, Doug Rhen, Jason Lelujian, and Ralf Jungman for helping develop prototype BDIs, which then stimulated development of the more general TDI.
PY - 2009
Y1 - 2009
N2 - Tissue mechanical properties reflect extracellular matrix composition and organization, and as such, their changes can be a signature of disease. Examples of such diseases include intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, and tooth decay. Here we introduce the tissue diagnostic instrument (TDI), a device designed to probe the mechanical properties of normal and diseased soft and hard tissues not only in the laboratory but also in patients. The TDI can distinguish between the nucleus and the annulus of spinal disks, between young and degenerated cartilage, and between normal and cancerous mammary glands. It can quantify the elastic modulus and hardness of the wet dentin left in a cavity after excavation. It can perform an indentation test of bone tissue, quantifying the indentation depth increase and other mechanical parameters. With local anesthesia and disposable, sterile, probe assemblies, there has been neither pain nor complications in tests on patients. We anticipate that this unique device will facilitate research on many tissue systems in living organisms, including plants, leading to new insights into disease mechanisms and methods for their early detection.
AB - Tissue mechanical properties reflect extracellular matrix composition and organization, and as such, their changes can be a signature of disease. Examples of such diseases include intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, and tooth decay. Here we introduce the tissue diagnostic instrument (TDI), a device designed to probe the mechanical properties of normal and diseased soft and hard tissues not only in the laboratory but also in patients. The TDI can distinguish between the nucleus and the annulus of spinal disks, between young and degenerated cartilage, and between normal and cancerous mammary glands. It can quantify the elastic modulus and hardness of the wet dentin left in a cavity after excavation. It can perform an indentation test of bone tissue, quantifying the indentation depth increase and other mechanical parameters. With local anesthesia and disposable, sterile, probe assemblies, there has been neither pain nor complications in tests on patients. We anticipate that this unique device will facilitate research on many tissue systems in living organisms, including plants, leading to new insights into disease mechanisms and methods for their early detection.
UR - http://www.scopus.com/inward/record.url?scp=66549115483&partnerID=8YFLogxK
U2 - 10.1063/1.3127602
DO - 10.1063/1.3127602
M3 - Article
C2 - 19485522
AN - SCOPUS:66549115483
SN - 0034-6748
VL - 80
JO - Review of Scientific Instruments
JF - Review of Scientific Instruments
IS - 5
M1 - 054303
ER -