The three Es of cancer immunoediting

Gavin P. Dunn, Lloyd J. Old, Robert D. Schreiber

Research output: Contribution to journalReview articlepeer-review

1947 Scopus citations

Abstract

After a century of controversy, the notion that the immune system regulates cancer development is experiencing a new resurgence. An overwhelming amount of data from animal models - together with compelling data from human patients - indicate that a functional cancer immunosurveillance process indeed exists that acts as an extrinsic tumor suppressor. However, it has also become clear that the immune system can facilitate tumor progression, at least in part, by sculpting the immunogenic phenotype of tumors as they develop. The recognition that immunity plays a dual role in the complex interactions between tumors and the host prompted a refinement of the cancer immunosurveillance hypothesis into one termed "cancer immunoediting." In this review, we summarize the history of the cancer immunosurveillance controversy and discuss its resolution and evolution into the three Es of cancer immunoediting - elimination, equilibrium, and escape.

Original languageEnglish
Pages (from-to)329-360
Number of pages32
JournalAnnual Review of Immunology
Volume22
DOIs
StatePublished - 2004

Keywords

  • Immunosurveillance
  • Interferon
  • Lymphocytes
  • Tumor
  • Tumor sculpting

Fingerprint

Dive into the research topics of 'The three Es of cancer immunoediting'. Together they form a unique fingerprint.

Cite this