TY - JOUR
T1 - The Tailgate Study
T2 - Differing metabolic effects of a bout of excessive eating and drinking
AU - Syed-Abdul, Majid M.
AU - Jacome-Sosa, Miriam
AU - Hu, Qiong
AU - Gaballah, Ayman H.
AU - Winn, Nathan C.
AU - Lee, Nhan T.
AU - Mucinski, Justine M.
AU - Manrique-Acevedo, Camila
AU - Lastra, Guido
AU - Anderson, Jennifer M.
AU - Al Juboori, Alhareth
AU - Bartholow, Bruce D.
AU - Parks, Elizabeth J.
N1 - Funding Information:
This study was sponsored by the Department of Nutrition and Exercise Physiology, University of Missouri, Columbia , Missouri. We sincerely thank the research subjects for their time and effort in participating in this study. Appreciation goes to Renan Codonhato for early development of the protocol, Whitney Reist, RD for designing the buffet, clinical coordinator Kimberlee Bingham for administrative organization, numerous undergraduate researchers who assisted with study activities, and the nurses at the Clinical Research Center for their excellent care of the participants.
Publisher Copyright:
© 2020 The Author(s)
PY - 2021/2
Y1 - 2021/2
N2 - Introduction: Excess energy intake by spectators at a sporting event (i.e., a tailgate) might cause acute negative health effects. However, limited data exist regarding the effects of overeating and alcohol consumption on lipid metabolism and the potential to gain intrahepatic triacylglycerols (IHTG). We tested the hypothesis that overconsumption of food and alcohol would significantly increase both hepatic de novo lipogenesis (DNL) and IHTG. Methods: Eighteen males (mean ± SD, age: 31.4 ± 7.3 years, BMI: 32.1 ± 5.9 kg/m2) were given alcoholic drinks to elevate blood alcohol for 5 h, while highly palatable food was presented. Blood samples were collected and DNL in TG-rich lipoproteins (TRL) was measured by GC/MS, IHTG was measured via MRS (n = 15), and substrate oxidation was measured via indirect calorimetry. Results: Subjects consumed 5087 ± 149 kcal (191 ± 25% excess of total daily energy needs including 171 ± 24 g alcohol), which increased plasma insulin, glucose, TG, and decreased NEFA (ANOVA p ≤ 0.003 for all). Both DNL and TRL-TG increased (p < 0.001), while IHTG did not change in the group as a whole (p = 0.229). Individual subject data revealed remarkably differing responses for IHTG (nine increased, five decreased, one did not change). Despite maintaining equal breath alcohol levels, subjects with IHTG elevations exhibited higher DNL, consumed 90% less alcohol (p = 0.048), tended to consume more carbohydrates, and exhibited lower whole-body fat oxidation (not significant) compared to those whose IHTG was reduced. Discussion: This study demonstrates that acute excess energy intake may have differing effects on an individual's DNL and IHTG, and dietary carbohydrate may influence DNL more than alcohol.
AB - Introduction: Excess energy intake by spectators at a sporting event (i.e., a tailgate) might cause acute negative health effects. However, limited data exist regarding the effects of overeating and alcohol consumption on lipid metabolism and the potential to gain intrahepatic triacylglycerols (IHTG). We tested the hypothesis that overconsumption of food and alcohol would significantly increase both hepatic de novo lipogenesis (DNL) and IHTG. Methods: Eighteen males (mean ± SD, age: 31.4 ± 7.3 years, BMI: 32.1 ± 5.9 kg/m2) were given alcoholic drinks to elevate blood alcohol for 5 h, while highly palatable food was presented. Blood samples were collected and DNL in TG-rich lipoproteins (TRL) was measured by GC/MS, IHTG was measured via MRS (n = 15), and substrate oxidation was measured via indirect calorimetry. Results: Subjects consumed 5087 ± 149 kcal (191 ± 25% excess of total daily energy needs including 171 ± 24 g alcohol), which increased plasma insulin, glucose, TG, and decreased NEFA (ANOVA p ≤ 0.003 for all). Both DNL and TRL-TG increased (p < 0.001), while IHTG did not change in the group as a whole (p = 0.229). Individual subject data revealed remarkably differing responses for IHTG (nine increased, five decreased, one did not change). Despite maintaining equal breath alcohol levels, subjects with IHTG elevations exhibited higher DNL, consumed 90% less alcohol (p = 0.048), tended to consume more carbohydrates, and exhibited lower whole-body fat oxidation (not significant) compared to those whose IHTG was reduced. Discussion: This study demonstrates that acute excess energy intake may have differing effects on an individual's DNL and IHTG, and dietary carbohydrate may influence DNL more than alcohol.
KW - Alcohol
KW - Carbohydrate
KW - Fats
KW - Intrahepatic triglycerides
KW - Overeating
UR - http://www.scopus.com/inward/record.url?scp=85098998854&partnerID=8YFLogxK
U2 - 10.1016/j.alcohol.2020.11.001
DO - 10.1016/j.alcohol.2020.11.001
M3 - Article
C2 - 33232792
AN - SCOPUS:85098998854
VL - 90
SP - 45
EP - 55
JO - Alcohol
JF - Alcohol
SN - 0741-8329
ER -