The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages

Catherine Porcher, Wojciech Swat, Karen Rockwell, Yuko Fujiwara, Frederick W. Alt, Stuart H. Orkin

Research output: Contribution to journalArticlepeer-review

603 Scopus citations

Abstract

The T cell leukemia oncoprotein SCL/tal-1, a basic-helix-loop-helix transcription factor, is required for production of embryonic red blood cells in the mouse yolk sac. To define roles in other lineages, we studied the hematopoietic potential of homozygous mutant SCL/tal- -/- embryonic stem cells upon in vitro differentiation and in vivo in chimeric mice. Here we show that in the absence of SCL/tal-1, hematopoiesis, including the generation of red cells, myeloid cells, megakaryocytes, mast cells, and both T and B lymphoid cells, is undetectable. These findings suggest that SCL/tal- 1 functions very early in hematopoietic development, either in specification of ventral mesoderm to a blood cell fate, or in formation or maintenance of immature progenitors.

Original languageEnglish
Pages (from-to)47-57
Number of pages11
JournalCell
Volume86
Issue number1
DOIs
StatePublished - Jul 12 1996

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