The systemic inflammatory response syndrome

Charles M. Robertson, Craig M. Coopersmith

Research output: Contribution to journalShort surveypeer-review

120 Scopus citations


The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. This review outlines the pathophysiology of SIRS and highlights potential targets for future therapeutic intervention in patients with this complex entity.

Original languageEnglish
Pages (from-to)1382-1389
Number of pages8
JournalMicrobes and Infection
Issue number5
StatePublished - Apr 2006


  • Adaptive immune system
  • Biomarkers
  • Critical illness
  • Hyperinflammatory
  • Hypoinflammatory
  • Inflammation
  • Innate immune system
  • Multiple organ dysfunction syndrome
  • Pathophysiology
  • Sepsis
  • Systemic inflammatory response syndrome


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