The synthesis of bicyclic lactam based His-Pro building blocks: The effect of substituent polarity on an intramolecular bond migration

Keyphrases

• Substituent Effect 100%
• Lactams 100%
• Amides 100%
• Intramolecular Bond 100%
• Bicyclic Lactams 100%
• Side Chain 50%
• Amino Acids 50%
• Cyclization 50%
• Synthetic Routes 50%
• Imidazole 50%
• Carbonyl 50%
• Seven-membered Ring 50%
• Six-membered Rings 50%
• Electron-withdrawing Group 50%
• Proline Derivatives 50%

Chemistry

• His-Pro 100%
• Lactam 100%
• Carboxamide 66%
• Lactam Ring 33%
• Proline Derivative 33%
• Imidazole 33%
• Amino Acid 33%
• six membered rings 33%