TY - JOUR
T1 - The structural immunology of antibody protection against West Nile virus
AU - Diamond, Michael S.
AU - Pierson, Theodore C.
AU - Fremont, Daved H.
PY - 2008/10
Y1 - 2008/10
N2 - Recent investigations of the interaction between the West Nile virus (WNV) envelope protein (E) and monoclonal antibodies (mAbs) have elucidated fundamental insights into the molecular mechanisms of neutralization. Structural studies have defined an epitope on the lateral ridge of domain III (DIII-lr) of the WNV E protein that is recognized by antibodies with the strongest neutralizing activity in vitro and in vivo. Antibodies that bind this epitope are highly potent because they efficiently block at a post-entry step of viral infection with relatively low virion occupancy requirements. In this review, we discuss the structural, molecular, and immunologic basis for antibody-mediated protection against WNV, and its implications for novel therapeutic or vaccine strategies.
AB - Recent investigations of the interaction between the West Nile virus (WNV) envelope protein (E) and monoclonal antibodies (mAbs) have elucidated fundamental insights into the molecular mechanisms of neutralization. Structural studies have defined an epitope on the lateral ridge of domain III (DIII-lr) of the WNV E protein that is recognized by antibodies with the strongest neutralizing activity in vitro and in vivo. Antibodies that bind this epitope are highly potent because they efficiently block at a post-entry step of viral infection with relatively low virion occupancy requirements. In this review, we discuss the structural, molecular, and immunologic basis for antibody-mediated protection against WNV, and its implications for novel therapeutic or vaccine strategies.
KW - Antibodies
KW - Antigens/peptides/epitopes
KW - Complement
KW - Emerging infectious disease
KW - Infectious diseases
UR - http://www.scopus.com/inward/record.url?scp=52049125010&partnerID=8YFLogxK
U2 - 10.1111/j.1600-065X.2008.00676.x
DO - 10.1111/j.1600-065X.2008.00676.x
M3 - Review article
C2 - 18837784
AN - SCOPUS:52049125010
SN - 0105-2896
VL - 225
SP - 212
EP - 225
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -