@article{7e15384ba02d49fe844e50e7cb9afbca,
title = "The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex",
abstract = "Early endocytic membrane traffic is regulated by the small GTPase Rab5, which cycles between GTP- and GDP-bound states as well as between membrane and cytosol. The latter cycle depends on GDI, which functions as a Rab vehicle in the aqueous environment of the cytosol. Here, we report that formation of the GDI:Rab5 complex is stimulated by a cytosolic factor that we purified and then identified as p38 MAPK. We find that p38 regulates GDI in the cytosolic cycle of Rab5 and modulates endocytosis in vivo. Our observations reveal the existence of a cross-talk between endocytosis and the p38-dependent stress response, thus providing molecular evidence that endocytosis can be regulated by the environment.",
author = "Valeria Cavalli and Francis Vilbois and Michela Corti and Marcote, {Maria J.} and Kumiko Tamura and Michael Karin and Steve Arkinstall and Jean Gruenberg",
note = "Funding Information: We wish to thank Marie-H{\'e}l{\`e}ne Beuchat and Monique Belet for expert technical assistance, Bernard Schwendimann and Karen Roulin for help with protein purification, Marc Ballivet and Olivier Schaad for helpful discussions, and Gisou van der Goot, Monserrat Camps, and Didier Picard for critical reading of the manuscript. M. J. M. was a recipient of a fellowship from the European Community. This work was supported by grants 31/37296.93 and 31/55325.98 from the Swiss National Science Foundation and by grant RG0260/19999-M from the International Human Frontier Science Program (to J. G). M. K. is an American Cancer Society Research Professor, and his work is supported by NIH grants ESO4151 and ESO6376.",
year = "2001",
doi = "10.1016/S1097-2765(01)00189-7",
language = "English",
volume = "7",
pages = "421--432",
journal = "Molecular cell",
issn = "1097-2765",
number = "2",
}