The steroid sulfatase locus on structurally abnormal inactive X chromosomes is expressed

L. Immken, T. Mohandas, R. S. Sparkes, L. J. Shapiro

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    4 Scopus citations

    Abstract

    In mammalian somatic cells, sex-chromosome dosage compensation is achieved by random inactivation of one of the two X chromosomes. The Xg blood group antigen (Xg) and steroid sulfatase (STS) loci on the distal end of the short arm of the X chromosome have been shown to escape this inactivation. However, it has been reported that on structurally abnormal inactive X chromosomes Xg and STS are inactivated. This discrepancy requires further consideration since whatever process accounts for the lack of inactivation of these loci on structurally normal, inactive X chromosomes might be anticipated to be operative on structurally abnormal, inactive X chromosomes. To investigate this issue, we examined the expression of STS activity in mouse-human somatic-cell hybrids retaining two different, deleted, inactive human X chromosomes. These studies provide evidence for lack of inactivation of STS on structurally abnormal, inactive X chromosomes.

    Original languageEnglish
    Pages (from-to)979-986
    Number of pages8
    JournalAmerican journal of human genetics
    Volume36
    Issue number5
    StatePublished - Dec 1 1984

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    Immken, L., Mohandas, T., Sparkes, R. S., & Shapiro, L. J. (1984). The steroid sulfatase locus on structurally abnormal inactive X chromosomes is expressed. American journal of human genetics, 36(5), 979-986.