One of the main tasks for pathologists when evaluating gastric biopsies from patients with portal hypertensive gastropathy (PHG) is to examine whether there is increased mucosal vasculature as suggested by endoscopy. However, the full spectrum of pathology findings in patients with portal hypertension (pHTN) is largely unknown. We systematically characterized the endoscopic and pathologic features in gastric biopsies from pHTN patients (study group) and compared with those from patients without pHTN (control group). The study group consisted of 550 consecutive surveillance esophagogastroduodenoscopic (EGD) biopsies, whereas the control group included 281 consecutive EGD biopsies for a variety of indications. As expected, the endoscopic prevalence of PHG was 28%, among which two-thirds showed corresponding histopathologic evidence of increased vasculature. However, non-Helicobacter pylori gastritis was the most common finding in pHTN patients on histology (40%). In addition, hyperplastic polyp was also more common in pHTN patients than in controls (6% vs 3%; P = 0.0314). In contrast, pathology findings of nonspecific reactive changes (29% vs 51%; P < 0.0001), proton pump inhibitor-related changes (16% vs 30%; P < 0.0001), and malignancy (1% vs 3%; P = 0.0138) were less common in pHTN patients. Our results show a spectrum of gastric endoscopic and pathologic findings in pHTN patients. The predominant gastric pathology in pHTN patients may be associated with pHTN-induced gastric microcirculation impairment.

Original languageEnglish
Pages (from-to)704-709
Number of pages6
JournalPathology Research and Practice
Issue number8
StatePublished - Aug 1 2016


  • Biopsy
  • Cirrhosis
  • Gastric antral vascular ectasia
  • Non-Helicobacter pylori gastritis


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