The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities

Abby M. Green; Matthew D. Weitzman

doi:10.1016/j.dnarep.2019.102700

The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities

Abby M. Green, Matthew D. Weitzman

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

The APOBEC3 family of cytosine deaminases are part of the innate immune response to viral infection, but also have the capacity to damage cellular DNA. Detection of mutational signatures consistent with APOBEC3 activity, together with elevated APOBEC3 expression in cancer cells, has raised the possibility that these enzymes contribute to oncogenesis. Genome deamination by APOBEC3 enzymes also elicits DNA damage response signaling and presents therapeutic vulnerabilities for cancer cells. Here, we discuss implications of APOBEC3 activity in cancer and the potential to exploit their mutagenic activity for targeted cancer therapies.

Original language	English
Article number	102700
Journal	DNA Repair
Volume	83
DOIs	https://doi.org/10.1016/j.dnarep.2019.102700
State	Published - Nov 2019

Keywords

APOBEC3
Cytosine deaminase
DNA damage response
Mutational patterns
Synthetic lethality

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10.1016/j.dnarep.2019.102700

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title = "The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities",

abstract = "The APOBEC3 family of cytosine deaminases are part of the innate immune response to viral infection, but also have the capacity to damage cellular DNA. Detection of mutational signatures consistent with APOBEC3 activity, together with elevated APOBEC3 expression in cancer cells, has raised the possibility that these enzymes contribute to oncogenesis. Genome deamination by APOBEC3 enzymes also elicits DNA damage response signaling and presents therapeutic vulnerabilities for cancer cells. Here, we discuss implications of APOBEC3 activity in cancer and the potential to exploit their mutagenic activity for targeted cancer therapies.",

keywords = "APOBEC3, Cytosine deaminase, DNA damage response, Mutational patterns, Synthetic lethality",

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N2 - The APOBEC3 family of cytosine deaminases are part of the innate immune response to viral infection, but also have the capacity to damage cellular DNA. Detection of mutational signatures consistent with APOBEC3 activity, together with elevated APOBEC3 expression in cancer cells, has raised the possibility that these enzymes contribute to oncogenesis. Genome deamination by APOBEC3 enzymes also elicits DNA damage response signaling and presents therapeutic vulnerabilities for cancer cells. Here, we discuss implications of APOBEC3 activity in cancer and the potential to exploit their mutagenic activity for targeted cancer therapies.

AB - The APOBEC3 family of cytosine deaminases are part of the innate immune response to viral infection, but also have the capacity to damage cellular DNA. Detection of mutational signatures consistent with APOBEC3 activity, together with elevated APOBEC3 expression in cancer cells, has raised the possibility that these enzymes contribute to oncogenesis. Genome deamination by APOBEC3 enzymes also elicits DNA damage response signaling and presents therapeutic vulnerabilities for cancer cells. Here, we discuss implications of APOBEC3 activity in cancer and the potential to exploit their mutagenic activity for targeted cancer therapies.

KW - APOBEC3

KW - Cytosine deaminase

KW - DNA damage response

KW - Mutational patterns

KW - Synthetic lethality

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SN - 1568-7864

VL - 83

JO - DNA Repair

JF - DNA Repair

M1 - 102700

ER -

The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities

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Keywords

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