The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities

Abby M. Green, Matthew D. Weitzman

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The APOBEC3 family of cytosine deaminases are part of the innate immune response to viral infection, but also have the capacity to damage cellular DNA. Detection of mutational signatures consistent with APOBEC3 activity, together with elevated APOBEC3 expression in cancer cells, has raised the possibility that these enzymes contribute to oncogenesis. Genome deamination by APOBEC3 enzymes also elicits DNA damage response signaling and presents therapeutic vulnerabilities for cancer cells. Here, we discuss implications of APOBEC3 activity in cancer and the potential to exploit their mutagenic activity for targeted cancer therapies.

Original languageEnglish
Article number102700
JournalDNA Repair
Volume83
DOIs
StatePublished - Nov 2019

Keywords

  • APOBEC3
  • Cytosine deaminase
  • DNA damage response
  • Mutational patterns
  • Synthetic lethality

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