The specificity of re‐innervation by identified sensory and motor neurons in the leech

D. C. Van Essen, J. K.S. Jansen

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Re‐innervation of skin and muscle by identified sensory and motor neurons in segmental ganglia of the leech was studied using physiological techniques. After lesions of peripheral nerves, sensory axons which re‐innervated the skin always regained sensitivity to their original stimulus modality (touch, pressure or noxious stimuli). Motor neurons invariably re‐innervated the appropriate type of body wall muscle, such as longitudinal or circular muscle layers. Both sensory and motor axons usually returned to the appropriate region of the body wall (dorsal, lateral, or ventral) when regenerating after a nerve crush or cut. This capacity was lost, however, when growth along old nerve branches was prevented by evulsing long segments of the nerve. Re‐innervation usually occurred by way of growth of new axons all the way the periphery, but in a few cases reconnection with the surviving distal segment of the original axon had taken place. The specificity of reinnervation can be accounted for by a combination of selective growth along appropriate nerve branches and specific interactions with target tissues.

Original languageEnglish
Pages (from-to)433-454
Number of pages22
JournalJournal of Comparative Neurology
Volume171
Issue number4
DOIs
StatePublished - Feb 15 1977
Externally publishedYes

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